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In explaining what has contributed to this consideration, we identified the importance of balancing our goal of driving the greatest possible shift to high-value care delivery, which we believe may be incentivized most effectively under a two-sided model, with a concern that requiring ACOs to take on too much downside risk too quickly may disincentivize program participation and reduce the program's potential to positively affect the quality and cost of care furnished to beneficiaries

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These early animal studies used both subcutaneous and oral administration routes, with subcutaneous delivery demonstrating greater bioavailability in pharmacokinetic assessments