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Importantly, in active intestinal inflammation, HIF-2α may exert context-dependent effects on ferroptosis susceptibility: even under systemic iron deficiency, local inflammatory cues can paradoxically enhance epithelial iron uptake and/or perturb subcellular iron distribution, thereby increasing the labile iron pool and promoting lipid peroxidation
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These signals are consistent with a moderated inflammatory milieu that may favor organized tissue remodeling
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