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As early as 1998, cytochrome P450 was introduced within HSV-I, enabling conversion processes whereby cyclophosphamide becomes activated specifically inside malignant tissues, leading toward notable anticancer effects evidenced across medulloblastoma atypical teratoid/rhabdomyosarcoma brain neoplasms among others (105, 106)
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A methionine-choline deficient (MCD) diet has been a well-established model for inducing the full spectrum of NAFLD in rodent studies as methionine, folate, and B12 deficiency all have been linked to NAFLD [104,105] (Figure 2A)
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